A Singleton Baby vs. Twins – Why You Should Consider Serial SET

Why One Baby Is Better, For You and the Baby

The number of twin births have almost doubled in the last four decades.  Besides the effect of maternal age (i.e. older women who are able to get pregnant are more likely to have twins than younger women), the Centers for Disease Control and Prevention (CDC) says more than one-third of twins and more than three-quarters of triplets and other high-order multiples resulted from assisted reproductive technology (ART).  The practice of transferring two or more embryos during IVF has contributed over the years to the increase in multiple births. But IVF treatment protocols are changing, based on improved results from single embryo transfers (SETs).


In 2017, the American Society for Reproductive Medicine (ASRM) and the Society for Assisted Reproductive Technology (SART) issued new guidelines calling for SET to be the standard first treatment of choice for all women under age 38, and for those up to age 42 if preimplantation genetic screening (PGS) determines an embryo has the normal number of chromosomes. Transferring a single embryo drastically reduces the chance of having twins and almost eliminates high-order multiples like triplets.

Many people want twins, and research has found part of the reason is to save on the expense of multiple IVF cycles.   So, why shouldn’t you try for your whole family in one shot?

Increased Risk for Babies and Mothers

Research has found that twins are more likely to be born prematurely, require a caesarian delivery, have low birth rate and a higher risk of birth defects, and, because of all this, to be more at risk of stillbirth than a single baby.  Compared with babies conceived from 2 IVF singleton pregnancies, IVF-derived twins have higher rates of respiratory complications, sepsis and jaundice.  This can mean the babies spend days or weeks in the hospital NICU.

Carrying twins is considered a high-risk pregnancy.  This means the mother is at risk of preeclampsia, a condition where her blood pressure goes dangerously high, gestational diabetes, and of a caesarian delivery.  It’s rare in the U.S., but the mother of multiples is more likely to die of preeclampsia and other complications.

Better Success Rates

Serial SET is use of single embryo transfer to conceive a baby with IVF and then using SET again after the first one is born, to conceive another child.  Recent studies have confirmed that the cumulative pregnancy rate with serial SET is higher than that of transferring a comparable number of embryos at one time.

Making Serial SET and IVF Affordable

If you’re ready to pursue IVF treatment, WIN Fertility can help.  WINFertility’s Nurse Care Managers or professionally-trained Patient Specialists can help you find an excellent reproductive endocrinologist in your area and get discounted treatment packages and financing options.

WINFertility provides lower than market-rate Treatment and Medication Bundles which combine medical services for a single IVF treatment, genetic testing (if required) and medications at a discounted “pay-as-you-go, one-stop-shopping” price saving you up to 40% off the total cost of your treatment cycle…while saving lots of time from shopping around and comparing prices.   The bundle is tailored for your specific treatment plan, and you only pay for the treatment you need, unlike traditional multi-cycle discount plans in which you pay for up to 6 attempts that you may never need in order to receive a discount.  For those patients who think they may need an additional IVF attempt to become pregnant, the WINFertility 2nd Chance IVF Refund Program helps control costs, maximizes your chance of success and minimizes your risk of overpaying.

Are you ready to take the next step?  Visit www.WINFertility.com or call 1-855-705-4483 (4IVF.)